4% of the students at Missouri Southern State University are registered with the college's disability services office.
| In-state | Out of state | |
| Cost of Attendance | $19,283 | $26,875 |
| Tuition | $7,244 | $14,836 |
| Room & Board (on-campus) | $7,678 | $7,678 |
| Books & Supplies | $902 | $902 |
| Transportation & Other | $3,459 | $3,459 |
| Percentage of students receiving some need-based aid | 97% | |
| Percentage of students receiving some Federal aid | 54% | |
| Percentage of students receiving some institutional aid | 69% | |
| Percentage of students with education loans | 52% |
Missouri Southern State University's Admissions Page
In 2020, the average GPA of students admitted to Missouri Southern State University was 3.20.
In 2020, 9% of applicants submitted SAT scores. Reported score ranges for admitted students:
| Score | Math | EBRW |
| 25th Percentile | 410 | 430 |
| 75th Percentile | 550 | 560 |
In 2020, 84% of applicants submitted ACT scores. Reported score ranges for admitted students:
| Score | Composite | Writing |
| 25th Percentile | 18 | - |
| 75th Percentile | 25 | - |