William Penn University competes in NAIA Division I.
| Name | Participants | |
|---|---|---|
| Men | Women | |
| Baseball | 45 | 0 |
| Basketball | 58 | 36 |
| Football | 109 | 0 |
| Golf | 16 | 18 |
| Soccer | 37 | 22 |
| Softball | 0 | 36 |
| Track and Field, Indoor | 32 | 17 |
| Track and Field, Outdoor | 29 | 23 |
| Track and Field, X-Country | 12 | 7 |
| Volleyball | 0 | 27 |
| Wrestling | 40 | 0 |
| Bowling | 23 | 10 |