McKendree University competes in NCAA Division II (with football).
| Name | Participants | |
|---|---|---|
| Men | Women | |
| Baseball | 47 | 0 |
| Basketball | 16 | 16 |
| All Track Combined | 131 | 90 |
| Football | 140 | 0 |
| Golf | 22 | 16 |
| Lacrosse | 0 | 23 |
| Soccer | 41 | 35 |
| Softball | 0 | 27 |
| Tennis | 17 | 13 |
| Volleyball | 21 | 28 |
| Wrestling | 46 | 0 |
| Bowling | 0 | 19 |