Knox College competes in NCAA Division III (with football).
| Name | Participants | |
|---|---|---|
| Men | Women | |
| Baseball | 33 | 0 |
| Basketball | 20 | 17 |
| Football | 49 | 0 |
| Golf | 6 | 0 |
| Soccer | 30 | 37 |
| Softball | 0 | 13 |
| Swimming | 13 | 26 |
| Tennis | 9 | 13 |
| Track and Field, Indoor | 26 | 21 |
| Track and Field, Outdoor | 25 | 25 |
| Track and Field, X-Country | 19 | 20 |
| Volleyball | 0 | 11 |